Zinc Protoporphyrin | 锌原卟啉
MCE 国际站:Zinc Protoporphyrin
中文名:锌原卟啉
CAS:15442-64-5
品牌:MedChemExpress (MCE)
存储条件:-20°C, sealed storage, away from moisture
生物活性:Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性和竞争性的血红素加氧酶-1 (HO-1) 抑制剂,可显着减弱 (PG) 对 H 的保护作用2O2[1]。锌原卟啉被用作个体孕妇和儿童铁缺乏症的筛查标志物,也可结合血红蛋白浓度评估人群铁状况[2]。锌原卟啉具有抗癌活性[3]。
体外:Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) 导致晚期凋亡和坏死细胞的比例从对照组的 10.9% 增加到 72 小时后的 30.4%[3]。
Zinc Protoporphyrin(1.25-40 μM;48 或 72 小时)对肿瘤细胞产生抑囊/细胞毒性作用[3]。
Zinc Protoporphyrin(2.5、5 μM;48 或 72 小时)导致细胞周期 G1 期细胞的剂量和时间依赖性减少[3]。
Zinc Protoporphyrin(1.25-40 μM;48 小时)导致裂解(活性)caspase-3 的积累[3]。
体内:原卟啉锌(12.5、25、50 mg/kg 腹腔注射;12.5、50 mg/kg 口服;从第 7 天到第 19 天)发挥剂量依赖性抗肿瘤作用,表现为延缓肿瘤生长[3]。
热销产品:Teriflunomide | VAL-083 | PSB36 | KS15 | Atibuclimab | Loncastuximab | Iguratimod | IL-7, Human (CHO, His) | Taurochenodeoxycholic acid | Biotin-Thalidomide
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Apoptosis
作用靶点:Reactive Oxygen Species | Endogenous Metabolite | Apoptosis
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
参考文献:
[1]. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17(4).
[2]. Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229.
[3]. Nowis D, et al. Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. BMC Cancer. 2008 Jul 11;8:197.